• Western blot analysis of mouse serum, using MBL2 antibody (STJ28388) at 1:500 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
  • Immunohistochemistry analysis of paraffin-embedded Human liver using MBL2 antibody (STJ28388) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol
  • Immunohistochemistry analysis of paraffin-embedded Human esophageal cancer using MBL2 antibody (STJ28388) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol
  • Immunohistochemistry analysis of paraffin-embedded human gastric carcinoma using MBL2 antibody (STJ28388) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol
  • Immunohistochemistry analysis of paraffin-embedded Human colorectal cancer using MBL2 antibody (STJ28388) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol

Anti-MBL2 antibody (21-248) (STJ28388)

SKU:
STJ28388

£169.50 - £449.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-MBL2 (21-248) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:100-1:500
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MBL2
Gene ID: 4153
Uniprot ID: MBL2_HUMAN
Immunogen Region: 21-248
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 21-248 of human MBL2 (NP_000233.1).
Immunogen Sequence: ETVTCEDAQKTCPAVIACSS PGINGFPGKDGRDGTKGEKG EPGQGLRGLQGPPGKLGPPG NPGPSGSPGPKGQKGDPGKS PDGDSSLAASERKALQTEMA RIKKWLTFSLGKQVGNKFFL TNGEIMTFEKVKALCVKFQA SVATPRNAAENGAIQNLIKE EAFLGITDEKTEGQFVDLTG NRLTYTNWNEGEPNNAGSDE DCVLLLKNGQWNDVPCSTSH LAVCEFPI
Tissue Specificity Plasma protein produced mainly in the liver.
Function Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response.
Protein Name Mannose-Binding Protein C
Mbp-C
Collectin-1
Mbp1
Mannan-Binding Protein
Mannose-Binding Lectin
Database Links Reactome: R-HSA-166662
Reactome: R-HSA-166663
Reactome: R-HSA-9705671
Cellular Localisation Secreted
Alternative Antibody Names Anti-Mannose-Binding Protein C antibody
Anti-Mbp-C antibody
Anti-Collectin-1 antibody
Anti-Mbp1 antibody
Anti-Mannan-Binding Protein antibody
Anti-Mannose-Binding Lectin antibody
Anti-MBL2 antibody
Anti-COLEC1 antibody
Anti-MBL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance