Anti-MBL2 antibody (21-248) (STJ28388)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MBL2 (21-248) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MBL2 |
| Gene ID | 4153 |
| Uniprot ID | MBL2_HUMAN |
| Immunogen Region | 21-248 |
| Immunogen Sequence | ETVTCEDAQKTCPAVIACSS PGINGFPGKDGRDGTKGEKG EPGQGLRGLQGPPGKLGPPG NPGPSGSPGPKGQKGDPGKS PDGDSSLAASERKALQTEMA RIKKWLTFSLGKQVGNKFFL TNGEIMTFEKVKALCVKFQA SVATPRNAAENGAIQNLIKE EAFLGITDEKTEGQFVDLTG NRLTYTNWNEGEPNNAGSDE DCVLLLKNGQWNDVPCSTSH LAVCEFPI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 21-248 of human MBL2 (NP_000233.1). |
Additional Info
| Tissue Specificity | Plasma protein produced mainly in the liver. |
| Function | Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. |
| Protein Name | Mannose-Binding Protein CMbp-CCollectin-1Mbp1Mannan-Binding ProteinMannose-Binding Lectin |
| Database Links | Reactome: R-HSA-166662Reactome: R-HSA-166663Reactome: R-HSA-9705671 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Mannose-Binding Protein C antibodyAnti-Mbp-C antibodyAnti-Collectin-1 antibodyAnti-Mbp1 antibodyAnti-Mannan-Binding Protein antibodyAnti-Mannose-Binding Lectin antibodyAnti-MBL2 antibodyAnti-COLEC1 antibodyAnti-MBL antibody |
Information sourced from Uniprot.org