Anti-MBL antibody [3+00E+07] (STJ16100773)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
General Information
| Short Description | Mouse monoclonal anti-MBL for use in IHC-F, FC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-F/FC/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3+00E+07 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 100 Mu g/mL |
| Formulation | PBS with 0.1% BSA and 0.02% sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | MBL2 |
| Gene ID | 4153 |
| Uniprot ID | MBL2_HUMAN |
Additional Info
| Tissue Specificity | Plasma protein produced mainly in the liver. |
| Function | Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. |
| Protein Name | Mannose-Binding Protein CMbp-CCollectin-1Mbp1Mannan-Binding ProteinMannose-Binding Lectin |
| Database Links | Reactome: R-HSA-166662Reactome: R-HSA-166663Reactome: R-HSA-9705671 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Mannose-Binding Protein C antibodyAnti-Mbp-C antibodyAnti-Collectin-1 antibodyAnti-Mbp1 antibodyAnti-Mannan-Binding Protein antibodyAnti-Mannose-Binding Lectin antibodyAnti-MBL2 antibodyAnti-COLEC1 antibodyAnti-MBL antibody |
Information sourced from Uniprot.org