Anti-MBD2 antibody [R05-4G5] (STJA0034546)

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STJA0034546
£140.50 - £308.50
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Short Description :Rabbit monoclonal anti-MBD2 for use in WB, IHC-F, IHC-P, ICC, IF and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/IHC-F/IHC-P/ICC/IF/IP
Host:Rabbit
Reactivity:Human/Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :R05-4G5
Isotype:IgG
Conjugation:Unconjugated
Concentration:0.3 mg/mL
Purification:Affinity Purified
Dilution Range:WB 1:500-1:1000
IHC 1:50-1:100
IF 1:50-1:200
IP 1:20
Formulation:50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage Instruction:Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol:MBD2
Gene ID:8932
Uniprot ID:MBD2_HUMAN
Immunogen:A synthetic peptide of human MBD2
Tissue Specificity Highly expressed in brain, heart, kidney, stomach, testis and placenta.
Function Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases to chromatin. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Acts as a transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Protein Name Methyl-Cpg-Binding Domain Protein 2
Demethylase
Dmtase
Methyl-Cpg-Binding Protein Mbd2
Database Links Reactome: R-HSA-427413
Reactome: R-HSA-73728
Cellular Localisation Nucleus
Chromosome
Nuclear
In Discrete Foci
Detected At Replication Foci In Late S Phase
Localizes To Methylated Chromatin
Localizes To Sites Of Dna Damage In A Manner Partially Dependent On Zmynd8
Alternative Antibody Names Anti-Methyl-Cpg-Binding Domain Protein 2 antibody
Anti-Demethylase antibody
Anti-Dmtase antibody
Anti-Methyl-Cpg-Binding Protein Mbd2 antibody
Anti-MBD2 antibody

Information sourced from Uniprot.org

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