Anti-Mast Cell Tryptase antibody [7C4-3H6-1E9] (STJA0033466)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenSynthesized peptide derived from human Mast cell tryptase
General Information
| Short Description | Mouse monoclonal anti-Mast Cell Tryptase for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 7C4-3H6-1E9 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Dilution Range | IHC 1:100-1:500 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TPSAB1 |
| Gene ID | 7177 |
| Uniprot ID | TRYB1_HUMAN |
| Immunogen | Synthesized peptide derived from human Mast cell tryptase |
Additional Info
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin.in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level). |
| Function | Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates. |
| Protein Name | Tryptase Alpha/Beta-1Tryptase-1Tryptase ITryptase Alpha-1 |
| Database Links | Reactome: R-HSA-1592389 |
| Cellular Localisation | SecretedReleased From The Secretory Granules Upon Mast Cell Activation |
| Alternative Antibody Names | Anti-Tryptase Alpha/Beta-1 antibodyAnti-Tryptase-1 antibodyAnti-Tryptase I antibodyAnti-Tryptase Alpha-1 antibodyAnti-TPSAB1 antibodyAnti-TPS1 antibodyAnti-TPS2 antibodyAnti-TPSB1 antibody |
Information sourced from Uniprot.org