Anti-MARVELD2 antibody (1-195) (STJ114486)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MARVELD2 (1-195) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MARVELD2 |
| Gene ID | 153562 |
| Uniprot ID | MALD2_HUMAN |
| Immunogen Region | 1-195 |
| Immunogen Sequence | MSNDGRSRNRDRRYDEVPSD LPYQDTTIRTHPTLHDSERA VSADPLPPPPLPLQPPFGPD FYSSDTEEPAIAPDLKPVRR FVPDSWKNFFRGKKKDPEWD KPVSDIRYISDGVECSPPAS PARPNHRSPLNSCKDPYGGS EGTFSSRKEADAVFPRDPYG SLDRHTQTVRTYSEKVEEYN LRYSYMKSWAGLLRI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-195 of human MARVELD2 (NP_001033692.2). |
Additional Info
| Post Translational Modifications | Ubiquitinated by ITCH.but this ubiquitination does not lead to proteasomal degradation. Polyubiquitinated at Lys-412 via 'Lys-63'-linked ubiquitin chains.deubiquitinated by USP53. Phosphorylated. |
| Function | Plays a role in the formation of tricellular tight junctions and of epithelial barriers. Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti. |
| Protein Name | Marvel Domain-Containing Protein 2Tricellulin |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell JunctionTight JunctionLocated At Tricellular Contacts |
| Alternative Antibody Names | Anti-Marvel Domain-Containing Protein 2 antibodyAnti-Tricellulin antibodyAnti-MARVELD2 antibodyAnti-TRIC antibody |
Information sourced from Uniprot.org