| Host: | Mouse |
| Applications: | IHC-P |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Mart-1 is suitable for use in Immunohistochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | M2-7C10 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2bk |
| Formulation: | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Dilution Range: | IHC 1:100 – 1:500 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Gene Symbol: | MLANA |
| Gene ID: | 2315 |
| Uniprot ID: | MAR1_HUMAN |
| Tissue Specificity | Expression is restricted to melanoma and melanocyte cell lines and retina. |
| Post Translational Modifications | Acylated. |
| Function | Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. |
| Protein Name | Melanoma Antigen Recognized By T-Cells 1 Mart-1 Antigen Lb39-Aa Antigen Sk29-Aa Protein Melan-A |
| Database Links | Reactome: R-HSA-9824585 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type Iii Membrane Protein Golgi Apparatus Trans-Golgi Network Membrane Melanosome Also Found In Small Vesicles And Tubules Dispersed Over The Entire Cytoplasm A Small Fraction Of The Protein Is Inserted Into The Membrane In An Inverted Orientation Inversion Of Membrane Topology Results In The Relocalization Of The Protein From A Predominant Golgi/Post-Golgi Area To The Endoplasmic Reticulum Melanoma Cells Expressing The Protein With An Inverted Membrane Topology Are More Effectively Recognized By Specific Cytolytic T-Lymphocytes Than Those Expressing The Protein In Its Native Membrane Orientation |
| Alternative Antibody Names | Anti-Melanoma Antigen Recognized By T-Cells 1 antibody Anti-Mart-1 antibody Anti-Antigen Lb39-Aa antibody Anti-Antigen Sk29-Aa antibody Anti-Protein Melan-A antibody Anti-MLANA antibody Anti-MART1 antibody |
Information sourced from Uniprot.org
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