| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-MAP/microtubule affinity-regulating kinase 3 (1-50 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MARK3 |
| Gene ID: | 4140 |
| Uniprot ID: | MARK3_HUMAN |
| Immunogen Region: | 1-50 aa |
| Specificity: | C-TAK1 Polyclonal Antibody detects endogenous levels of C-TAK1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human MARK3 at the amino acid range 1-50 |
| Post Translational Modifications | Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-564 by PRKCZ/aPKC inhibits the kinase activity. |
| Function | Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1. |
| Protein Name | Map/Microtubule Affinity-Regulating Kinase 3C-Tak1Ctak1Cdc25c-Associated Protein Kinase 1Elkl Motif Kinase 2Emk-2Protein Kinase Stk10Ser/Thr Protein Kinase Par-1Par-1aSerine/Threonine-Protein Kinase P78 |
| Database Links | Reactome: R-HSA-5673000Reactome: R-HSA-5674135Reactome: R-HSA-5675221Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9856649 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCell ProjectionDendriteCytoplasm |
| Alternative Antibody Names | Anti-Map/Microtubule Affinity-Regulating Kinase 3 antibodyAnti-C-Tak1 antibodyAnti-Ctak1 antibodyAnti-Cdc25c-Associated Protein Kinase 1 antibodyAnti-Elkl Motif Kinase 2 antibodyAnti-Emk-2 antibodyAnti-Protein Kinase Stk10 antibodyAnti-Ser/Thr Protein Kinase Par-1 antibodyAnti-Par-1a antibodyAnti-Serine/Threonine-Protein Kinase P78 antibodyAnti-MARK3 antibodyAnti-CTAK1 antibodyAnti-EMK2 antibody |
Information sourced from Uniprot.org
