Anti-MARCO antibody (421-520) (STJ112088)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MARCO (421-520) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MARCO |
| Gene ID | 8685 |
| Uniprot ID | MARCO_HUMAN |
| Immunogen Region | 421-520 |
| Immunogen Sequence | SVSVRIVGSSNRGRAEVYYS GTWGTICDDEWQNSDAIVFC RMLGYSKGRALYKVGAGTGQ IWLDNVQCRGTESTLWSCTK NSWGHHDCSHEEDAGVECSV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 421-520 of human MARCO (NP_006761.1). |
Additional Info
| Tissue Specificity | Expressed in alveolar macrophages (at protein level). Detected in macrophages from various tissues including thymus, kidney, Kupffer cells of liver, and spleen. |
| Post Translational Modifications | N-glycosylated. |
| Function | Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages. Binds to the secretoglobin SCGB3A2. |
| Protein Name | Macrophage Receptor MarcoMacrophage Receptor With Collagenous StructureScavenger Receptor Class A Member 2 |
| Database Links | Reactome: R-HSA-3000480 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Macrophage Receptor Marco antibodyAnti-Macrophage Receptor With Collagenous Structure antibodyAnti-Scavenger Receptor Class A Member 2 antibodyAnti-MARCO antibodyAnti-SCARA2 antibody |
Information sourced from Uniprot.org