Anti-MARCKSL1 antibody (1-195) (STJ29212)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MARCKSL1 (1-195) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MARCKSL1 |
| Gene ID | 65108 |
| Uniprot ID | MRP_HUMAN |
| Immunogen Region | 1-195 |
| Immunogen Sequence | MGSQSSKAPRGDVTAEEAAG ASPAKANGQENGHVKSNGDL SPKGEGESPPVNGTDEAAGA TGDAIEPAPPSQGAEAKGEV PPKETPKKKKKFSFKKPFKL SGLSFKRNRKEGGGDSSASS PTEEEQEQGEIGACSDEGTA QEGKAAATPESQEPQAKGAE ASAASEEEAGPQATEPSTPS GPESGPTPASAEQNE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-195 of human MARCKSL1 (NP_075385.1). |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation at Ser-120 and Thr-178 is non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8. May be phosphorylated by protein kinase C, which disrupts the interaction with calmodulin. |
| Function | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. |
| Protein Name | Marcks-Related ProteinMarcks-Like Protein 1Macrophage Myristoylated Alanine-Rich C Kinase SubstrateMac-MarcksMacmarcks |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell MembraneLipid-AnchorAssociates With The Membrane Via The Insertion Of The N-Terminal N-Myristoyl Chain And The Partial Insertion Of The Effector DomainAssociation Of The Effector Domain With Membranes May Be Regulated By Ca(2+)/CalmodulinColocalizes With F-Actin At The Leading Edge Of Migrating CellsIn Prostate CancersShows Strong Expression At Apical And/Or Basal Regions Of The Cell And Also Has Weak Cytoplasmic Expression |
| Alternative Antibody Names | Anti-Marcks-Related Protein antibodyAnti-Marcks-Like Protein 1 antibodyAnti-Macrophage Myristoylated Alanine-Rich C Kinase Substrate antibodyAnti-Mac-Marcks antibodyAnti-Macmarcks antibodyAnti-MARCKSL1 antibodyAnti-MLP antibodyAnti-MRP antibody |
Information sourced from Uniprot.org