Anti-MAPK6 antibody [R04-5B8] (STJA0034542)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human MAPK6
General Information
| Short Description | Rabbit monoclonal anti-MAPK6 for use in WB, IHC-P and IP in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R04-5B8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | MAPK6 |
| Gene ID | 5597 |
| Uniprot ID | MK06_HUMAN |
| Immunogen | A synthetic peptide of human MAPK6 |
Additional Info
| Tissue Specificity | Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts. |
| Post Translational Modifications | Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. Ubiquitination at Met-1 leads to degradation by the proteasome pathway. |
| Function | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle. |
| Protein Name | Mitogen-Activated Protein Kinase 6Map Kinase 6Mapk 6Extracellular Signal-Regulated Kinase 3Erk-3Map Kinase Isoform P97P97-Mapk |
| Database Links | Reactome: R-HSA-5687128 |
| Cellular Localisation | CytoplasmNucleusTranslocates To The Cytoplasm Following Interaction With Mapkapk5 |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase 6 antibodyAnti-Map Kinase 6 antibodyAnti-Mapk 6 antibodyAnti-Extracellular Signal-Regulated Kinase 3 antibodyAnti-Erk-3 antibodyAnti-Map Kinase Isoform P97 antibodyAnti-P97-Mapk antibodyAnti-MAPK6 antibodyAnti-ERK3 antibodyAnti-PRKM6 antibody |
Information sourced from Uniprot.org