Anti-MAPK4 antibody (500-550) (STJ501705)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenSynthetic peptide taken within amino acid region 500-550 on human Mitogen-activated protein kinase 4.
General Information
| Short Description | Chicken polyclonal antibody anti-MAPK4 (500-550) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Chicken |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Concentration | 0.5 ยตg/ยตl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500ELISA: 1:10, 000IP: 1:150 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | MAPK4 |
| Gene ID | 5596 |
| Uniprot ID | MK04_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 500-550 on human Mitogen-activated protein kinase 4. |
| Immunogen Region | 500-550 |
Additional Info
| Tissue Specificity | High expression in heart and brain. |
| Post Translational Modifications | Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. |
| Function | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle. |
| Protein Name | Mitogen-Activated Protein Kinase 4Map Kinase 4Mapk 4Extracellular Signal-Regulated Kinase 4Erk-4Map Kinase Isoform P63P63-Mapk |
| Database Links | Reactome: R-HSA-5687128 |
| Cellular Localisation | CytoplasmNucleusTranslocates To The Cytoplasm Following Interaction With Mapkapk5 |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase 4 antibodyAnti-Map Kinase 4 antibodyAnti-Mapk 4 antibodyAnti-Extracellular Signal-Regulated Kinase 4 antibodyAnti-Erk-4 antibodyAnti-Map Kinase Isoform P63 antibodyAnti-P63-Mapk antibodyAnti-MAPK4 antibodyAnti-ERK4 antibodyAnti-PRKM4 antibody |
Information sourced from Uniprot.org