Host: |
Rabbit |
Applications: |
WB/ELISA |
Reactivity: |
Human/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-Mitogen-activated protein kinase 4 (410-490 aa) is suitable for use in Western Blot and ELISA research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: |
1 mg/mL |
Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
MAPK4 |
Gene ID: |
5596 |
Uniprot ID: |
MK04_HUMAN |
Immunogen Region: |
410-490 aa |
Specificity: |
MK04 Polyclonal Antibody detects endogenous levels of protein. |
Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 410-490 |
Post Translational Modifications | Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. |
Function | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle. |
Protein Name | Mitogen-Activated Protein Kinase 4Map Kinase 4Mapk 4Extracellular Signal-Regulated Kinase 4Erk-4Map Kinase Isoform P63P63-Mapk |
Database Links | Reactome: R-HSA-5687128 |
Cellular Localisation | CytoplasmNucleusTranslocates To The Cytoplasm Following Interaction With Mapkapk5 |
Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase 4 antibodyAnti-Map Kinase 4 antibodyAnti-Mapk 4 antibodyAnti-Extracellular Signal-Regulated Kinase 4 antibodyAnti-Erk-4 antibodyAnti-Map Kinase Isoform P63 antibodyAnti-P63-Mapk antibodyAnti-MAPK4 antibodyAnti-ERK4 antibodyAnti-PRKM4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance