• Immunohistochemistry with Anti-MAPK13 Antibody (STJ501690) at 1:100 dilution in Buffer. DAB (brown) staining and Haematoxylin QS (blue) counterstain. 40X magnification. FFPE section.

Anti-MAPK13 antibody (310-360) (STJ501690)

SKU:
STJ501690-100

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Host: Chicken
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Chicken polyclonal antibody anti-MAPK13 (310-360) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgY
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:150
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: MAPK13
Gene ID: 5603
Uniprot ID: MK13_HUMAN
Immunogen Region: 310-360
Immunogen: Synthetic peptide taken within amino acid region 310-360 on human Mitogen-activated protein kinase 13.
Tissue Specificity Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.
Post Translational Modifications Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP1.
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.
Protein Name Mitogen-Activated Protein Kinase 13
Map Kinase 13
Mapk 13
Mitogen-Activated Protein Kinase P38 Delta
Map Kinase P38 Delta
Stress-Activated Protein Kinase 4
Database Links Reactome: R-HSA-168638
Reactome: R-HSA-171007
Reactome: R-HSA-376172
Reactome: R-HSA-4420097
Alternative Antibody Names Anti-Mitogen-Activated Protein Kinase 13 antibody
Anti-Map Kinase 13 antibody
Anti-Mapk 13 antibody
Anti-Mitogen-Activated Protein Kinase P38 Delta antibody
Anti-Map Kinase P38 Delta antibody
Anti-Stress-Activated Protein Kinase 4 antibody
Anti-MAPK13 antibody
Anti-PRKM13 antibody
Anti-SAPK4 antibody

Information sourced from Uniprot.org

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