| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MAPK13 (1-365) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MAPK13 |
| Gene ID: |
5603 |
| Uniprot ID: |
MK13_HUMAN |
| Immunogen Region: |
1-365 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human MAPK13 (NP_002745.1). |
| Immunogen Sequence: |
MSLIRKKGFYKQDVNKTAWE LPKTYVSPTHVGSGAYGSVC SAIDKRSGEKVAIKKLSRPF QSEIFAKRAYRELLLLKHMQ HENVIGLLDVFTPASSLRNF YDFYLVMPFMQTDLQKIMGM EFSEEKIQYLVYQMLKGLKY IHSAGVVHRDLKPGNLAVNE DCELKILDFGLARHADAEMT GYVVTRWYRAPEVILSWMHY NQTVDIWSVGCIMAEMLTGK TLFKGKDYLDQLTQILKVT |
| Tissue Specificity | Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells. |
| Post Translational Modifications | Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP1. |
| Function | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. |
| Protein Name | Mitogen-Activated Protein Kinase 13Map Kinase 13Mapk 13Mitogen-Activated Protein Kinase P38 DeltaMap Kinase P38 DeltaStress-Activated Protein Kinase 4 |
| Database Links | Reactome: R-HSA-168638Reactome: R-HSA-171007Reactome: R-HSA-376172Reactome: R-HSA-4420097 |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase 13 antibodyAnti-Map Kinase 13 antibodyAnti-Mapk 13 antibodyAnti-Mitogen-Activated Protein Kinase P38 Delta antibodyAnti-Map Kinase P38 Delta antibodyAnti-Stress-Activated Protein Kinase 4 antibodyAnti-MAPK13 antibodyAnti-PRKM13 antibodyAnti-SAPK4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
