Anti-MAP4K4 antibody (406-455 aa) (STJ93495)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human MEKKK 4 at the amino acid range 406-455
General Information
| Short Description | Rabbit polyclonal anti-Mitogen-activated protein kinase kinase kinase kinase 4 (406-455 aa) for use in WB, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAP4K4 |
| Gene ID | 9448 |
| Uniprot ID | M4K4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human MEKKK 4 at the amino acid range 406-455 |
| Immunogen Region | 406-455 aa |
| Specificity | HGK Polyclonal Antibody detects endogenous levels of HGK protein. |
Additional Info
| Function | Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. Phosphorylates SMAD1 on Thr-322. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4Hpk/Gck-Like Kinase HgkMapk/Erk Kinase Kinase Kinase 4Mek Kinase Kinase 4Mekkk 4Nck-Interacting Kinase |
| Database Links | Reactome: R-HSA-2559580 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 antibodyAnti-Hpk/Gck-Like Kinase Hgk antibodyAnti-Mapk/Erk Kinase Kinase Kinase 4 antibodyAnti-Mek Kinase Kinase 4 antibodyAnti-Mekkk 4 antibodyAnti-Nck-Interacting Kinase antibodyAnti-MAP4K4 antibodyAnti-HGK antibodyAnti-KIAA0687 antibodyAnti-NIK antibody |
Information sourced from Uniprot.org