Anti-MAP4K3 antibody (755-894) (STJ29490)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MAP4K3 (755-894) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAP4K3 |
| Gene ID | 8491 |
| Uniprot ID | M4K3_HUMAN |
| Immunogen Region | 755-894 |
| Immunogen Sequence | ETVNPNSTSSWFTESDTPQT NVTHVTQLERDTILVCLDCC IKIVNLQGRLKSSRKLSSEL TFDFQIESIVCLQDSVLAFW KHGMQGRSFRSNEVTQEISD STRIFRLLGSDRVVVLESRP TDNPTANSNLYILAGHENSY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 755-894 of human MAP4K3 (NP_003609.2). |
Additional Info
| Tissue Specificity | Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver. |
| Function | Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3Germinal Center Kinase-Related Protein KinaseGlkMapk/Erk Kinase Kinase Kinase 3Mek Kinase Kinase 3Mekkk 3 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 antibodyAnti-Germinal Center Kinase-Related Protein Kinase antibodyAnti-Glk antibodyAnti-Mapk/Erk Kinase Kinase Kinase 3 antibodyAnti-Mek Kinase Kinase 3 antibodyAnti-Mekkk 3 antibodyAnti-MAP4K3 antibodyAnti-RAB8IPL1 antibody |
Information sourced from Uniprot.org