Anti-MAP4K1 antibody (371-420 aa) (STJ93590)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human MEKKK 1 at the amino acid range 371-420
General Information
| Short Description | Rabbit polyclonal anti-Mitogen-activated protein kinase kinase kinase kinase 1 (371-420 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAP4K1 |
| Gene ID | 11184 |
| Uniprot ID | M4K1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human MEKKK 1 at the amino acid range 371-420 |
| Immunogen Region | 371-420 aa |
| Specificity | HPK1 Polyclonal Antibody detects endogenous levels of HPK1 protein. |
Additional Info
| Post Translational Modifications | Autophosphorylates: phosphorylation promotes ubiquitination by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex, leading to its degradation by the proteasome. Tyrosine-phosphorylated after activation of hemopoietic cells. Ubiquitinated by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex following autophosphorylation, leading to its degradation by the proteasome. |
| Function | Serine/threonine-protein kinase, which plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. May play a role in hematopoietic lineage decisions and growth regulation. Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1Hematopoietic Progenitor KinaseMapk/Erk Kinase Kinase Kinase 1Mek Kinase Kinase 1Mekkk 1 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 antibodyAnti-Hematopoietic Progenitor Kinase antibodyAnti-Mapk/Erk Kinase Kinase Kinase 1 antibodyAnti-Mek Kinase Kinase 1 antibodyAnti-Mekkk 1 antibodyAnti-MAP4K1 antibodyAnti-HPK1 antibody |
Information sourced from Uniprot.org