Anti-MAP3K3 antibody (1-220) (STJ118498)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MAP3K3 (1-220) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAP3K3 |
| Gene ID | 4215 |
| Uniprot ID | M3K3_HUMAN |
| Immunogen Region | 1-220 |
| Immunogen Sequence | MDEQEALNSIMNDLVALQMN RRHRMPGYETMKNKDTGHSN RQKKHNSSSSALLNSPTVTT SSCAGASEKKKFLSDVRIKF EHNGERRIIAFSRPVKYEDV EHKVTTVFGQPLDLHYMNNE LSILLKNQDDLDKAIDILDR SSSMKSLRILLLSQDRNHNS SSPHSGVSRQVRIKASQSAG DINTIYQPPEPRSRHLSVSS QNPGRSSPPPGYVPERQQHI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human MEKK3 (NP_976226.1). |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity. |
| Function | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase 3Mapk/Erk Kinase Kinase 3Mek Kinase 3Mekk 3 |
| Database Links | Reactome: R-HSA-9020702 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase 3 antibodyAnti-Mapk/Erk Kinase Kinase 3 antibodyAnti-Mek Kinase 3 antibodyAnti-Mekk 3 antibodyAnti-MAP3K3 antibodyAnti-MAPKKK3 antibodyAnti-MEKK3 antibody |
Information sourced from Uniprot.org