| Post Translational Modifications | Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated. The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation. |
| Function | Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase 12Dual Leucine Zipper Bearing KinaseDlkLeucine-Zipper Protein KinaseZpkMapk-Upstream KinaseMukMixed Lineage Kinase |
| Database Links | |
| Cellular Localisation | CytoplasmCell MembraneBehaves Essentially As An Integral Membrane Protein |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase 12 antibodyAnti-Dual Leucine Zipper Bearing Kinase antibodyAnti-Dlk antibodyAnti-Leucine-Zipper Protein Kinase antibodyAnti-Zpk antibodyAnti-Mapk-Upstream Kinase antibodyAnti-Muk antibodyAnti-Mixed Lineage Kinase antibodyAnti-MAP3K12 antibodyAnti-ZPK antibody |
Information sourced from Uniprot.org
