| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MAP2K3 (1-70) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MAP2K3 |
| Gene ID: |
5606 |
| Uniprot ID: |
MP2K3_HUMAN |
| Immunogen Region: |
1-70 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human MEK3 (NP_659731.1). |
| Immunogen Sequence: |
MESPASSQPASMPQSKGKSK RKKDLRISCMSKPPAPNPTP PRNLDSRTFITIGDRNFEVE ADDLVTISEL |
| Tissue Specificity | Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues. |
| Post Translational Modifications | Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. Phosphorylated by TAOK2. (Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. |
| Function | Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. |
| Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 3Map Kinase Kinase 3Mapkk 3Mapk/Erk Kinase 3Mek 3Stress-Activated Protein Kinase Kinase 2Sapk Kinase 2Sapkk-2Sapkk2 |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-450302Reactome: R-HSA-5210891 P46734-3 |
| Alternative Antibody Names | Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 antibodyAnti-Map Kinase Kinase 3 antibodyAnti-Mapkk 3 antibodyAnti-Mapk/Erk Kinase 3 antibodyAnti-Mek 3 antibodyAnti-Stress-Activated Protein Kinase Kinase 2 antibodyAnti-Sapk Kinase 2 antibodyAnti-Sapkk-2 antibodyAnti-Sapkk2 antibodyAnti-MAP2K3 antibodyAnti-MEK3 antibodyAnti-MKK3 antibodyAnti-PRKMK3 antibodyAnti-SKK2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
