• Anti-MANF antibody (STJA0002863)
  • Anti-MANF antibody (STJA0002863)
  • Anti-MANF antibody (STJA0002863)

Anti-MANF antibody (STJA0002863)

SKU:
STJA0002863-500

£1,560.50
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Host: Rabbit
Applications: ELISA/WB/IF/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-MANF is suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Concentrated ammonium sulphate in PBS pH 7.4.
Purification: MANF-affinity purified
Dilution Range: ELISA 0.1 to 0.2 µg/ml; WB 0.15 to 0.5 µg/ml, IHC 10 µg/ml, IF 1 to 20 µg/ml No cross-reactivity in MANF-knockout mouse. No cross-reactivity with CDNF in IHC, slightly cross-reacts with purified CDNF in WB. Polyclonal antibody working titer has to be
Storage Instruction: Storage Store at +4°C upon receipt. As product is (NH4) 2SO4 precipitate, mix well by pipetting or vortexing prior use
Gene Symbol: MANF
Gene ID: 7873
Uniprot ID: MANF_HUMAN
Specificity: Human MANF
Immunogen: Recombinant human MANF protein produced using CHO-based proprietary suspension cell line. Immunogen is purified from cell culture supernatant. Human MANF
Post Translational Modifications May contain sialic acid residues.
Function Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions.
Protein Name Mesencephalic Astrocyte-Derived Neurotrophic Factor
Arginine-Rich Protein
Protein Armet
Database Links Reactome: R-HSA-114608
Cellular Localisation Secreted
Endoplasmic Reticulum Lumen
Sarcoplasmic Reticulum Lumen
Retained In The Endoplasmic Reticulum (Er)
And Sarcoplasmic Reticulum (Sr) Under Normal Conditions
Up-Regulated And Secreted By The Er/Sr In Response To Er Stress And Hypoxia
Alternative Antibody Names Anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor antibody
Anti-Arginine-Rich Protein antibody
Anti-Protein Armet antibody
Anti-MANF antibody
Anti-ARMET antibody
Anti-ARP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance