Anti-MAML1/Mastermind antibody (N-Term) (STJ70419)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-MAML1/Mastermind (N-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 110kDa band observed in Human Skeletal Muscle lysates (calculated MW of 108kDa according to NP_055572.1). Recommended concentration: 0.1-0.3µg/ml.IHC: In paraffin embedded |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | MAML1 |
| Gene ID | 9794 |
| Uniprot ID | MAML1_HUMAN |
| Accession Number | NP_055572.1 |
| Immunogen Region | N-Term |
| Immunogen Sequence | VLPTCPMAEFALPR |
Additional Info
| Function | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. |
| Protein Name | Mastermind-Like Protein 1Mam-1 |
| Database Links | Reactome: R-HSA-1912408Reactome: R-HSA-210744Reactome: R-HSA-2122947Reactome: R-HSA-2197563Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-350054Reactome: R-HSA-8941856Reactome: R-HSA-9013508Reactome: R-HSA-9013695Reactome: R-HSA-9793380 |
| Cellular Localisation | Nucleus SpeckleNuclearIn A Punctate Manner |
| Alternative Antibody Names | Anti-Mastermind-Like Protein 1 antibodyAnti-Mam-1 antibodyAnti-MAML1 antibodyAnti-KIAA0200 antibody |
Information sourced from Uniprot.org