| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MALT1 (125-450) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MALT1 |
| Gene ID: |
10892 |
| Uniprot ID: |
MALT1_HUMAN |
| Immunogen Region: |
125-450 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 125-450 of human MALT1 (NP_776216.1). |
| Immunogen Sequence: |
PGIKITVNPESKAVLAGQFV KLCCRATGHPFVQYQWFKMN KEIPNGNTSELIFNAVHVKD AGFYVCRVNNNFTFEFSQWS QLDVCDIPESFQRSVDGVSE SKLQICVEPTSQKLMPGSTL VLQCVAVGSPIPHYQWFKNE LPLTHETKKLYMVPYVDLEH QGTYWCHVYNDRDSQDSKKV EIIIDELNNLGHPDNKEQTT DQPLAKDKVALLIGNMNYRE HPKLKAPLVDVYELTNLLR |
| Tissue Specificity | Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. |
| Function | Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. |
| Protein Name | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1Malt Lymphoma-Associated TranslocationParacaspase |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-202424Reactome: R-HSA-2871837Reactome: R-HSA-5607764Reactome: R-HSA-5660668 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusShuttles Between The Nucleus And CytoplasmFound In Perinuclear Structures Together With Bcl10 |
| Alternative Antibody Names | Anti-Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 antibodyAnti-Malt Lymphoma-Associated Translocation antibodyAnti-Paracaspase antibodyAnti-MALT1 antibodyAnti-MLT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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