| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MAGI3 (1190-1240 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
MAGI3 |
| Gene ID: |
260425 |
| Uniprot ID: |
MAGI3_HUMAN |
| Immunogen Region: |
1190-1240 aa |
| Specificity: |
Specific for MAGI3. |
| Immunogen: |
A synthetic peptide from aa region 1190-1240 of human MAGI3 conjugated to an immunogenic carrier protein was used as the antigen. |
| Post Translational Modifications | Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex. |
| Function | Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. |
| Protein Name | Membrane-Associated Guanylate Kinase - Ww And Pdz Domain-Containing Protein 3Membrane-Associated Guanylate Kinase Inverted 3Magi-3 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCell JunctionTight JunctionNucleusConcentrates In Specific Sites At The Plasma Membrane And In The NucleusIn Epithelial CellsIt Localizes At Tight Junctions |
| Alternative Antibody Names | Anti-Membrane-Associated Guanylate Kinase - Ww And Pdz Domain-Containing Protein 3 antibodyAnti-Membrane-Associated Guanylate Kinase Inverted 3 antibodyAnti-Magi-3 antibodyAnti-MAGI3 antibodyAnti-KIAA1634 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
