Anti-MAGI2 antibody (221-270 aa) (STJ93992)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human MAGI2 at the amino acid range 221-270
General Information
| Short Description | Rabbit polyclonal anti-Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (221-270 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAGI2 |
| Gene ID | 9863 |
| Uniprot ID | MAGI2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human MAGI2 at the amino acid range 221-270 |
| Immunogen Region | 221-270 aa |
| Specificity | MAGI-2 Polyclonal Antibody detects endogenous levels of MAGI-2 protein. |
Additional Info
| Function | Seems to act as a scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in receptor-mediated clathrin-dependent endocytosis which is required for ciliogenesis. |
| Protein Name | Membrane-Associated Guanylate Kinase - Ww And Pdz Domain-Containing Protein 2Atrophin-1-Interacting Protein 1Aip-1Atrophin-1-Interacting Protein AMembrane-Associated Guanylate Kinase Inverted 2Magi-2 |
| Database Links | Reactome: R-HSA-373753 |
| Cellular Localisation | CytoplasmLate EndosomeSynapseSynaptosomeCell MembranePeripheral Membrane ProteinCytoskeletonMicrotubule Organizing CenterCentrosomeCell ProjectionCiliumCentriolePhotoreceptor Inner SegmentPhotoreceptor Outer SegmentLocalized Diffusely In The Cytoplasm Before Nerve Growth Factor (Ngf) StimulationRecruited To Late Endosomes After Ngf StimulationMembrane-Associated In Synaptosomes |
| Alternative Antibody Names | Anti-Membrane-Associated Guanylate Kinase - Ww And Pdz Domain-Containing Protein 2 antibodyAnti-Atrophin-1-Interacting Protein 1 antibodyAnti-Aip-1 antibodyAnti-Atrophin-1-Interacting Protein A antibodyAnti-Membrane-Associated Guanylate Kinase Inverted 2 antibodyAnti-Magi-2 antibodyAnti-MAGI2 antibodyAnti-ACVRINP1 antibodyAnti-AIP1 antibodyAnti-KIAA0705 antibody |
Information sourced from Uniprot.org