Anti-MAGEA3 antibody [SAA1562] (STJA0019990)

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STJA0019990
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Short Description :Mouse monoclonal Melanoma-Associated antigen 3 antibody for use in ELISA and FC in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:ELISA/FC
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Clonality :Monoclonal
Clone ID :SAA1562
Isotype:IgG2a
Conjugation:Unconjugated
Concentration:1 mg/mL
Purification:Protein A/G purified from cell culture supernatant
Formulation:0.01M PBS, pH 7.4.
Storage Instruction:Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months
Gene Symbol:MAGEA3
Gene ID:4102
Uniprot ID:MAGA3_HUMAN
Post Translational Modifications Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation.
Function Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Protein Name Melanoma-Associated Antigen 3
Antigen Mz2-D
Cancer/Testis Antigen 1.3
Ct1.3
Mage-3 Antigen
Database Links
Cellular Localisation
Alternative Antibody Names Anti-Melanoma-Associated Antigen 3 antibody
Anti-Antigen Mz2-D antibody
Anti-Cancer/Testis Antigen 1.3 antibody
Anti-Ct1.3 antibody
Anti-Mage-3 Antigen antibody
Anti-MAGEA3 antibody
Anti-MAGE3 antibody

Information sourced from Uniprot.org

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