Anti-MAGEA1 antibody (STJA0037983)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human MAGEA1
General Information
| Short Description | Rabbit monoclonal anti-MAGEA1 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | IHC 1:100-1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | MAGEA1 |
| Gene ID | 4100 |
| Uniprot ID | MAGA1_HUMAN |
| Immunogen | A synthesized peptide derived from human MAGEA1 |
Additional Info
| Tissue Specificity | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas. |
| Function | May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. |
| Protein Name | Melanoma-Associated Antigen 1Antigen Mz2-ECancer/Testis Antigen 1.1Ct1.1Mage-1 Antigen |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Melanoma-Associated Antigen 1 antibodyAnti-Antigen Mz2-E antibodyAnti-Cancer/Testis Antigen 1.1 antibodyAnti-Ct1.1 antibodyAnti-Mage-1 Antigen antibodyAnti-MAGEA1 antibodyAnti-MAGE1 antibodyAnti-MAGE1A antibody |
Information sourced from Uniprot.org