Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-MAFK (1-50) is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
MAFK |
Gene ID: |
7975 |
Uniprot ID: |
MAFK_HUMAN |
Immunogen Region: |
1-50 |
Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-50 of human MAFK (NP_002351.1). |
Immunogen Sequence: |
MTTNPKPNKALKVKKEAGEN APVLSDDELVSMSVRELNQH LRGLTKEEVT |
Function | Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. |
Protein Name | Transcription Factor MafkErythroid Transcription Factor Nf-E2 P18 Subunit |
Database Links | Reactome: R-HSA-9707587Reactome: R-HSA-9707616Reactome: R-HSA-9708530Reactome: R-HSA-9818027Reactome: R-HSA-983231 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Transcription Factor Mafk antibodyAnti-Erythroid Transcription Factor Nf-E2 P18 Subunit antibodyAnti-MAFK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance