Anti-MAFB antibody (184-323) (STJ112117)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MAFB (184-323) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAFB |
| Gene ID | 9935 |
| Uniprot ID | MAFB_HUMAN |
| Immunogen Region | 184-323 |
| Immunogen Sequence | PTSHPGPGPHATASATAAGG NGSVEDRFSDDQLVSMSVRE LNRHLRGFTKDEVIRLKQKR RTLKNRGYAQSCRYKRVQQK HHLENEKTQLIQQVEQLKQE VSRLARERDAYKVKCEKLAN SGFREAGSTSDSPSSPEFFL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 184-323 of human MAFB (NP_005452.2). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated by GSK3 and MAPK13 on serine and threonine residues. Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors. |
| Function | Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain. |
| Protein Name | Transcription Factor MafbMaf-BV-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog B |
| Database Links | Reactome: R-HSA-5617472 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Mafb antibodyAnti-Maf-B antibodyAnti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog B antibodyAnti-MAFB antibodyAnti-KRML antibody |
Information sourced from Uniprot.org