Anti-MADCAM1 antibody [SAA0147] {PE} (STJA0031486)
SPECIFICATIONS
ClonalityMonoclonal
HostHuman
ConjugationPE
IsotypeIgG2k
General Information
| Short Description | Human monoclonal Mucosal Addressin Cell Adhesion Molecule 1 antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Human |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0147 |
| Isotype | IgG2k |
| Conjugation | PE |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | MADCAM1 |
| Gene ID | 8174 |
| Uniprot ID | MADCA_HUMAN |
Additional Info
| Post Translational Modifications | The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation. |
| Function | Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding. |
| Protein Name | Mucosal Addressin Cell Adhesion Molecule 1Madcam-1Hmadcam-1 |
| Database Links | Reactome: R-HSA-198933 Q13477-1Reactome: R-HSA-216083 Q13477-1 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Mucosal Addressin Cell Adhesion Molecule 1 antibodyAnti-Madcam-1 antibodyAnti-Hmadcam-1 antibodyAnti-MADCAM1 antibody |
Information sourced from Uniprot.org