• Western blot analysis of lysates from wild type (WT) and M6PR knockout (KO) 293T cells, using [KO Validated] M6PR Rabbit polyclonal antibody (STJ11100783) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-M6PR antibody (27-185) (STJ11100783)

SKU:
STJ11100783

£212.50 - £501.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-M6PR (27-185) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: M6PR
Gene ID: 4074
Uniprot ID: MPRD_HUMAN
Immunogen Region: 27-185
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 27-185 of human M6PR (NP_002346.1).
Immunogen Sequence: TEEKTCDLVGEKGKESEKEL ALVKRLKPLFNKSFESTVGQ GSDTYIYIFRVCREAGNHTS GAGLVQINKSNGKETVVGRL NETHIFNGSNWIMLIYKGGD EYDNHCGKEQRRAVVMISCN RHTLADNFNPVSEERGKVQD CFYLFEMDSSLACSPEISH
Function Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Protein Name Cation-Dependent Mannose-6-Phosphate Receptor
Cd Man-6-P Receptor
Cd-Mpr
46 Kda Mannose 6-Phosphate Receptor
Mpr 46
Database Links Reactome: R-HSA-432720
Reactome: R-HSA-6811440
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Cellular Localisation Lysosome Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Cation-Dependent Mannose-6-Phosphate Receptor antibody
Anti-Cd Man-6-P Receptor antibody
Anti-Cd-Mpr antibody
Anti-46 Kda Mannose 6-Phosphate Receptor antibody
Anti-Mpr 46 antibody
Anti-M6PR antibody
Anti-MPR46 antibody
Anti-MPRD antibody

Information sourced from Uniprot.org

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