| Short Description : | Rabbit polyclonal LZTS2 (470-669) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LZTS2 |
| Gene ID: | 84445 |
| Uniprot ID: | LZTS2_HUMAN |
| Immunogen Region: | 470-669 |
| Immunogen Sequence: | ELVALRVALREARATLRVSE GRARGLQEAARARELELEAC SQELQRHRQEAEQLREKAGQ LDAEAAGLREPPVPPATADP FLLAESDEAKVQRAAAGVGG SLRAQVERLRVELQRERRRG EEQRDSFEGERLAWQAEKEQ VIRYQKQLQHNYIQMYRRNR QLEQELQQLSLELEARELAD LGLAEQAPCICLEEITATEI |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 470-669 of human LZTS2 (NP_115805.1). |
| Tissue Specificity | Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon. |
| Function | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. |
| Protein Name | Leucine Zipper Putative Tumor Suppressor 2Hlzts2Protein Lapser1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeLocalized To The Centrosome Throughout The Cell CycleLocalized To The Midbody In Cells Undergoing Cytokinesis |
| Alternative Antibody Names | Anti-Leucine Zipper Putative Tumor Suppressor 2 antibodyAnti-Hlzts2 antibodyAnti-Protein Lapser1 antibodyAnti-LZTS2 antibodyAnti-KIAA1813 antibodyAnti-LAPSER1 antibody |
Information sourced from Uniprot.org
