| Function | Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the 2Fe-2S clusters assembly on the scaffolding protein ISCU. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a 2Fe-2S cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the 2Fe-2S cluster assembly. Finally, the 2Fe-2S cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. May also participates in the iron-sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1. |
| Protein Name | Lyr Motif-Containing Protein 4 |
| Database Links | Reactome: R-HSA-1362409Reactome: R-HSA-9854311Reactome: R-HSA-9865881 |
| Cellular Localisation | MitochondrionNucleus |
| Alternative Antibody Names | Anti-Lyr Motif-Containing Protein 4 antibodyAnti-LYRM4 antibodyAnti-C6orf149 antibodyAnti-ISD11 antibodyAnti-CGI-203 antibody |
Information sourced from Uniprot.org
