Anti-Lunatic Fringe antibody [R42-8V-5] (STJA0035630)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Lunatic Fringe
General Information
| Short Description | Rabbit monoclonal anti-Lunatic Fringe for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R42-8V-5 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | LFNG |
| Gene ID | 3955 |
| Uniprot ID | LFNG_HUMAN |
| Immunogen | A synthesized peptide derived from human Lunatic Fringe |
Additional Info
| Post Translational Modifications | A soluble form may be derived from the membrane form by proteolytic processing. |
| Function | Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning. |
| Protein Name | Beta-1 -3-N-Acetylglucosaminyltransferase Lunatic FringeO-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-5083630Reactome: R-HSA-9824272Reactome: R-HSA-9831926 |
| Cellular Localisation | Golgi ApparatusGolgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Beta-1 -3-N-Acetylglucosaminyltransferase Lunatic Fringe antibodyAnti-O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase antibodyAnti-LFNG antibody |
Information sourced from Uniprot.org