Anti-LTK antibody [R02-8A4] (STJA0035257)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human LTK
General Information
| Short Description | Rabbit monoclonal anti-LTK for use in WB and IHC-P in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R02-8A4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | LTK |
| Gene ID | 4058 |
| Uniprot ID | LTK_HUMAN |
| Immunogen | A synthetic peptide of human LTK |
Additional Info
| Tissue Specificity | Expressed in non-hematopoietic cell lines and T- and B-cell lines. |
| Post Translational Modifications | Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. |
| Function | Receptor with a tyrosine-protein kinase activity. Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. The exact function of this protein is not known.studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. |
| Protein Name | Leukocyte Tyrosine Kinase ReceptorProtein Tyrosine Kinase 1 |
| Database Links | Reactome: R-HSA-9842663 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Tyrosine Kinase Receptor antibodyAnti-Protein Tyrosine Kinase 1 antibodyAnti-LTK antibodyAnti-TYK1 antibody |
Information sourced from Uniprot.org