| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LTB4R |
| Gene ID: | 1241 |
| Uniprot ID: | LT4R1_HUMAN |
| Immunogen Region: | 320-337 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 253-352 of human LTB4R (NP_001137391.1). |
| Immunogen Sequence: | AAGLGLVGKRLSLARNVLIA LAFLSSSVNPVLYACAGGGL LRSAGVGFVAKLLEGTGSEA SSTRRGGSLGQTARSGPAAL EPGPSESLTASSPLKLNELN |
| Tissue Specificity | Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues. |
| Post Translational Modifications | Phosphorylated by GRK6 upon leukotriene B4 binding.which promotes desensitization. |
| Function | Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. |
| Protein Name | Leukotriene B4 Receptor 1 Ltb4-R 1 Ltb4-R1 Chemoattractant Receptor-Like 1 G-Protein Coupled Receptor 16 P2y Purinoceptor 7 P2y7 |
| Database Links | Reactome: R-HSA-391906 Reactome: R-HSA-416476 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Leukotriene B4 Receptor 1 antibody Anti-Ltb4-R 1 antibody Anti-Ltb4-R1 antibody Anti-Chemoattractant Receptor-Like 1 antibody Anti-G-Protein Coupled Receptor 16 antibody Anti-P2y Purinoceptor 7 antibody Anti-P2y7 antibody Anti-LTB4R antibody Anti-BLT antibody Anti-BLT1 antibody Anti-BLTR antibody Anti-CMKRL1 antibody Anti-GPR16 antibody Anti-P2RY7 antibody |
Information sourced from Uniprot.org