Anti-LTA antibody (35-205) (STJ11103847)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Lymphotoxin-Alpha (35-205) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LTA |
| Gene ID | 4049 |
| Uniprot ID | TNFB_HUMAN |
| Immunogen Region | 35-205 |
| Immunogen Sequence | LPGVGLTPSAAQTARQHPKM HLAHSTLKPAAHLIGDPSKQ NSLLWRANTDRAFLQDGFSL SNNSLLVPTSGIYFVYSQVV FSGKAYSPKATSSPLYLAHE VQLFSSQYPFHVPLLSSQKM VYPGLQEPWLHSMYHGAAFQ LTQGDQLSTHTDGIPHLVLS PSTVFFGAFAL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 35-205 of human LTA (NP_000586.2). |
Additional Info
| Function | Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. |
| Protein Name | Lymphotoxin-AlphaLt-AlphaTnf-BetaTumor Necrosis Factor Ligand Superfamily Member 1 |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5669034Reactome: R-HSA-5676594 |
| Cellular Localisation | SecretedMembraneThe Homotrimer Is SecretedThe Heterotrimer Is Membrane-Associated |
| Alternative Antibody Names | Anti-Lymphotoxin-Alpha antibodyAnti-Lt-Alpha antibodyAnti-Tnf-Beta antibodyAnti-Tumor Necrosis Factor Ligand Superfamily Member 1 antibodyAnti-LTA antibodyAnti-TNFB antibodyAnti-TNFSF1 antibody |
Information sourced from Uniprot.org