Anti-LSS antibody (1-300) (STJ29010)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LSS (1-300) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LSS |
| Gene ID | 4047 |
| Uniprot ID | LSS_HUMAN |
| Immunogen Region | 1-300 |
| Immunogen Sequence | MTEGTCLRRRGGPYKTEPAT DLGRWRLNCERGRQTWTYLQ DERAGREQTGLEAYALGLDT KNYFKDLPKAHTAFEGALNG MTFYVGLQAEDGHWTGDYGG PLFLLPGLLITCHVARIPLP AGYREEIVRYLRSVQLPDGG WGLHIEDKSTVFGTALNYVS LRILGVGPDDPDLVRARNIL HKKGGAVAIPSWGKFWLAVL NVYSWEGLNTLFPEMWLFPD WAPAHPSTLWCHCRQVYLP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LSS (NP_002331.3). |
Additional Info
| Tissue Specificity | Widely expressed. Expressed in the hair bulb, the outer root sheath and hair matrix of the hair follicle epithelium. Also detected in dermal papilla, epidermis, sweat glands, sebaceous glands, and blood vessels. |
| Function | Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. |
| Protein Name | Lanosterol Synthase2 -3-Epoxysqualene--Lanosterol CyclaseOxidosqualene--Lanosterol CyclaseOscHosc |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-2426168 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Lanosterol Synthase antibodyAnti-2 -3-Epoxysqualene--Lanosterol Cyclase antibodyAnti-Oxidosqualene--Lanosterol Cyclase antibodyAnti-Osc antibodyAnti-Hosc antibodyAnti-LSS antibodyAnti-OSC antibody |
Information sourced from Uniprot.org