Anti-Lsh/HELLS antibody (614-838 aa) [SRM5364] (STJ11107274)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Lsh/HELLS (614-838 aa) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5364 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:22000-1:132000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HELLS |
| Gene ID | 3070 |
| Uniprot ID | HELLS_HUMAN |
| Immunogen Region | 614-838 aa |
| Immunogen Sequence | RGHKVLLFSQMTSMLDILMD YCHLRDFNFSRLDGSMSYSE REKNMHSFNTDPEVFIFLVS TRAGGLGINLTAADTVIIYD SDWNPQSDLQAQDRCHRIGQ TKPVVVYRLVTANTIDQKIV ERAAAKRKLEKLIIHKNHFK GGQSGLNLSKNFLDPKELME LLKSRDYEREIKGSREKVIS DKDLELLLDRSDLIDQMNAS GPIKEKMGIFKILENSEDSS PECLF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 614-838 of human Lsh/HELLS (NP_060533.2). |
Additional Info
| Tissue Specificity | Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias. |
| Function | Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis. |
| Protein Name | Lymphoid-Specific HelicaseProliferation-Associated Snf2-Like ProteinSwi/Snf2-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 6 |
| Database Links | Reactome: R-HSA-9839394 |
| Cellular Localisation | NucleusClosely Associated With Pericentric Heterochromatin |
| Alternative Antibody Names | Anti-Lymphoid-Specific Helicase antibodyAnti-Proliferation-Associated Snf2-Like Protein antibodyAnti-Swi/Snf2-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 6 antibodyAnti-HELLS antibodyAnti-PASG antibodyAnti-SMARCA6 antibodyAnti-Nbla10143 antibody |
Information sourced from Uniprot.org