Anti-LSD2/KDM1B/AOF1 antibody (1-100) [S0MR] (STJ11103160)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal LSD2/KDM1B/AOF1 (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S0MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KDM1B |
| Gene ID | 221656 |
| Uniprot ID | KDM1B_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MATPRGRTKKKASFDHSPDS LPLRSSGRQAKKKATETTDE DEDGGSEKKYRKCEKAGCTA TCPVCFASASERCAKNGYTS RWYHLSCGEHFCNECFDHYY |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LSD2/KDM1B/AOF1 (NP_694587.3). |
Additional Info
| Function | Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes. |
| Protein Name | Lysine-Specific Histone Demethylase 2Flavin-Containing Amine Oxidase Domain-Containing Protein 1Lysine-Specific Histone Demethylase 1b |
| Database Links | Reactome: R-HSA-3214842Reactome: R-HSA-5689603Reactome: R-HSA-9029569 |
| Cellular Localisation | NucleusChromosomeFound In Actively Rnapolii-Transcribed Gene Bodies |
| Alternative Antibody Names | Anti-Lysine-Specific Histone Demethylase 2 antibodyAnti-Flavin-Containing Amine Oxidase Domain-Containing Protein 1 antibodyAnti-Lysine-Specific Histone Demethylase 1b antibodyAnti-KDM1B antibodyAnti-AOF1 antibodyAnti-C6orf193 antibodyAnti-LSD2 antibody |
Information sourced from Uniprot.org