| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LRSAM1 |
| Gene ID: | 90678 |
| Uniprot ID: | LRSM1_HUMAN |
| Immunogen Region: | 1-290 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human LRSAM1 (NP_612370.3). |
| Immunogen Sequence: | MPLFFRKRKPSEEARKRLEY QMCLAKEAGADDILDISKCE LSEIPFGAFATCKVLQKKVL IVHTNHLTSLLPKSCSLLSL ATIKVLDLHDNQLTALPDDL GQLTALQVLNVERNQLMQLP RSIGNLTQLQTLNVKDNKLK ELPDTVGELRSLRTLNISGN EIQRLPQMLAHVRTLEMLSL DASAMVYPPREVCGAGTAAI LQFLCKESGLEYYPPSQYLL PILEQDGIENSRDSPDGPT |
| Tissue Specificity | Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue. |
| Post Translational Modifications | Ubiquitination promoted by PHF23 leads to proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy). |
| Protein Name | E3 Ubiquitin-Protein Ligase Lrsam1 Leucine-Rich Repeat And Sterile Alpha Motif-Containing Protein 1 Ring-Type E3 Ubiquitin Transferase Lrsam1 Tsg101-Associated Ligase Htal |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm Displays A Punctuate Distribution And Localizes To A Submembranal Ring Localizes To Intracellular Bacterial Pathogens |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Lrsam1 antibody Anti-Leucine-Rich Repeat And Sterile Alpha Motif-Containing Protein 1 antibody Anti-Ring-Type E3 Ubiquitin Transferase Lrsam1 antibody Anti-Tsg101-Associated Ligase antibody Anti-Htal antibody Anti-LRSAM1 antibody Anti-TAL antibody Anti-UNQ6496 antibody Anti-PRO21356 antibody |
Information sourced from Uniprot.org