Anti-LRSAM1 antibody (1-290) (STJ111927)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LRSAM1 (1-290) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LRSAM1 |
| Gene ID | 90678 |
| Uniprot ID | LRSM1_HUMAN |
| Immunogen Region | 1-290 |
| Immunogen Sequence | MPLFFRKRKPSEEARKRLEY QMCLAKEAGADDILDISKCE LSEIPFGAFATCKVLQKKVL IVHTNHLTSLLPKSCSLLSL ATIKVLDLHDNQLTALPDDL GQLTALQVLNVERNQLMQLP RSIGNLTQLQTLNVKDNKLK ELPDTVGELRSLRTLNISGN EIQRLPQMLAHVRTLEMLSL DASAMVYPPREVCGAGTAAI LQFLCKESGLEYYPPSQYLL PILEQDGIENSRDSPDGPT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human LRSAM1 (NP_612370.3). |
Additional Info
| Tissue Specificity | Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue. |
| Post Translational Modifications | Ubiquitination promoted by PHF23 leads to proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy). |
| Protein Name | E3 Ubiquitin-Protein Ligase Lrsam1Leucine-Rich Repeat And Sterile Alpha Motif-Containing Protein 1Ring-Type E3 Ubiquitin Transferase Lrsam1Tsg101-Associated LigaseHtal |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmDisplays A Punctuate Distribution And Localizes To A Submembranal RingLocalizes To Intracellular Bacterial Pathogens |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Lrsam1 antibodyAnti-Leucine-Rich Repeat And Sterile Alpha Motif-Containing Protein 1 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Lrsam1 antibodyAnti-Tsg101-Associated Ligase antibodyAnti-Htal antibodyAnti-LRSAM1 antibodyAnti-TAL antibodyAnti-UNQ6496 antibodyAnti-PRO21356 antibody |
Information sourced from Uniprot.org