Anti-LRRK1 antibody (1950-2015) (STJ501636)

Name: Anti-LRRK1 antibody (1950-2015) (STJ501636)
SKU: STJ501636-100
Price: 480.6 EUR
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

ImmunogenSynthetic peptide taken within amino acid region 1950-2015 on human Leucine-rich repeat serine/threonine-protein kinase 1 protein.

STJ501636-100

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Short Description	Rabbit polyclonal antibody anti-LRRK1 (1950-2015) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Applications	ELISA/IP/WB
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	0.5-1.5 µg/µl
Purification	Affinity Purified
Dilution Range	WB: 1:2, 500-1:5, 000 ELISA: 1:50, 000 IP: 1:200
Formulation	Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	LRRK1
Gene ID	79705
Uniprot ID	LRRK1_HUMAN
Immunogen	Synthetic peptide taken within amino acid region 1950-2015 on human Leucine-rich repeat serine/threonine-protein kinase 1 protein.
Immunogen Region	1950-2015

Post Translational Modifications	Autophosphorylated. Autophosphorylation is inhibited in its dimeric state. Phosphorylated by protein kinase C isozymes PRKCA, PRKCB, PRKCG, PRKCE, PRKCZ and PRKCT at Thr-1061, Ser-1064, Ser-1074 and Thr-1075. Phosphorylation at these Ser-1064, Ser-1074 and Thr-1075 activates the kinase activity of LRRK1 to phosphorylate RAB7A.
Function	Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking. Phosphorylates RAB7A.this activity is dependent on protein kinase C (PKC) activation. Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts.
Protein Name	Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1
Cellular Localisation	Cytoplasm Cell Membrane Peripheral Membrane Protein
Alternative Antibody Names	Anti-Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 antibody Anti-LRRK1 antibody Anti-KIAA1790 antibody

Information sourced from Uniprot.org