| Post Translational Modifications | Autophosphorylated. Autophosphorylation is inhibited in its dimeric state. Phosphorylated by protein kinase C isozymes PRKCA, PRKCB, PRKCG, PRKCE, PRKCZ and PRKCT at Thr-1061, Ser-1064, Ser-1074 and Thr-1075. Phosphorylation at these Ser-1064, Ser-1074 and Thr-1075 activates the kinase activity of LRRK1 to phosphorylate RAB7A. |
| Function | Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking. Phosphorylates RAB7A.this activity is dependent on protein kinase C (PKC) activation. Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts. |
| Protein Name | Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 antibodyAnti-LRRK1 antibodyAnti-KIAA1790 antibody |
Information sourced from Uniprot.org
