| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Volume-regulated anion channel subunit LRRC8C is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LRRC8C |
| Gene ID: |
84230 |
| Uniprot ID: |
LRC8C_HUMAN |
| Specificity: |
This antibody detects endogenous levels of LRRC8C at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human LRRC8C |
| Function | Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E).channel characteristics depend on the precise subunit composition. |
| Protein Name | Volume-Regulated Anion Channel Subunit Lrrc8cFactor For Adipocyte Differentiation 158Leucine-Rich Repeat-Containing Protein 8c |
| Database Links | Reactome: R-HSA-5223345 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneIn The Absence Of Lrrc8aResides Primarily In A Cytoplasmic CompartmentProbably The Endoplasmic ReticulumRequires Lrrc8a For Expression At The Cell Membrane |
| Alternative Antibody Names | Anti-Volume-Regulated Anion Channel Subunit Lrrc8c antibodyAnti-Factor For Adipocyte Differentiation 158 antibodyAnti-Leucine-Rich Repeat-Containing Protein 8c antibodyAnti-LRRC8C antibodyAnti-AD158 antibodyAnti-FAD158 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
