| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LRRC14 |
| Gene ID: | 9684 |
| Uniprot ID: | LRC14_HUMAN |
| Immunogen Region: | 1-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human LRRC14 (NP_055480.1). |
| Immunogen Sequence: | MHTLVFLSTRQVLQCQPAAC QALPLLPRELFPLLFKVAFM DKKTVVLRELVHTWPFPLLS FQQLLQECAHCSRALLQERP STESMQAVILGLTARLHTSE PGASTQPLCRKHALRVLDMT GLLDDGVEQDPGTMSMWDCT AAVARTCIAQQQGGAAEPGP APIPVEVRVDLRVNRASYAF LREALRSSVGSPLRLCCRDL RAEDLPMRNTVALLQLLDAG CLRRVDLRFNNLGLRGLSV |
| Function | Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB. |
| Protein Name | Leucine-Rich Repeat-Containing Protein 14 |
| Database Links | Reactome: R-HSA-9758274 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat-Containing Protein 14 antibodyAnti-LRRC14 antibodyAnti-KIAA0014 antibody |
Information sourced from Uniprot.org