Anti-LRPPRC antibody (1041-1394) (STJ24427)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LRPPRC (1041-1394) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:5000IHC-P:1:50-1:200IF/ICC:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LRPPRC |
| Gene ID | 10128 |
| Uniprot ID | LPPRC_HUMAN |
| Immunogen Region | 1041-1394 |
| Immunogen Sequence | IACRLNQKKGAYDIFLNAKE QNIVFNAETYSNLIKLLMSE DYFTQAMEVKAFAETHIKGF TLNDAANSRLIITQVRRDYL KEAVTTLKTVLDQQQTPSRL AVTRVIQALAMKGDVENIEV VQKMLNGLEDSIGLSKMVFI NNIALAQIKNNNIDAAIENI ENMLTSENKVIEPQYFGLAY LFRKVIEEQLEPAVEKISIM AERLANQFAIYKPVTDFFLQ LVDAGKVDDARALLQRCGA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1041-1394 of human LRPPRC (NP_573566.2). |
Additional Info
| Tissue Specificity | Expressed ubiquitously. Expression is highest in heart, skeletal muscle, kidney and liver, intermediate in brain, non-mucosal colon, spleen and placenta, and lowest in small intestine, thymus, lung and peripheral blood leukocytes. |
| Function | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. Positively modulates nuclear export of mRNAs containing the EIF4E sensitivity element (4ESE) by binding simultaneously to both EIF4E and the 4ESE and acting as a platform for assembly for the RNA export complex. Also binds to exportin XPO1/CRM1 to engage the nuclear pore and traffic the bound mRNAs to the cytoplasm. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA. Required for maintaining mitochondrial potential. Suppresses the initiation of basal levels of autophagy and mitophagy by sustaining BCL2 levels. |
| Protein Name | Leucine-Rich Ppr Motif-Containing Protein - Mitochondrial130 Kda Leucine-Rich ProteinLrp 130Gp130 |
| Database Links | Reactome: R-HSA-9836573 |
| Cellular Localisation | MitochondrionNucleusNucleoplasmNucleus Inner MembraneNucleus Outer MembraneSeems To Be Predominantly Mitochondrial |
| Alternative Antibody Names | Anti-Leucine-Rich Ppr Motif-Containing Protein - Mitochondrial antibodyAnti-130 Kda Leucine-Rich Protein antibodyAnti-Lrp 130 antibodyAnti-Gp130 antibodyAnti-LRPPRC antibodyAnti-LRP130 antibody |
Information sourced from Uniprot.org