Anti-LRP4 antibody (290-370 aa) (STJ190937)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 290-370
General Information
| Short Description | Rabbit polyclonal anti-Low-density lipoprotein receptor-related protein 4 (290-370 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LRP4 |
| Gene ID | 4038 |
| Uniprot ID | LRP4_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 290-370 |
| Immunogen Region | 290-370 aa |
| Specificity | LRP4 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation. |
| Protein Name | Low-Density Lipoprotein Receptor-Related Protein 4Lrp-4Multiple Epidermal Growth Factor-Like Domains 7 |
| Database Links | Reactome: R-HSA-3000178 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Low-Density Lipoprotein Receptor-Related Protein 4 antibodyAnti-Lrp-4 antibodyAnti-Multiple Epidermal Growth Factor-Like Domains 7 antibodyAnti-LRP4 antibodyAnti-KIAA0816 antibodyAnti-LRP10 antibodyAnti-MEGF7 antibody |
Information sourced from Uniprot.org