• Western blot analysis of the lysates from HUVECcells using CD91 antibody.
  • Western blot analysis of lysates from HepG2 cells, using CD91 Antibody. The lane on the right is blocked with the synthesized peptide.

Anti-LRP1 antibody (4486-4535 aa) (STJ93954)

SKU:
STJ93954

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Prolow-density lipoprotein receptor-related protein 1 (4486-4535 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: LRP1
Gene ID: 4035
Uniprot ID: LRP1_HUMAN
Immunogen Region: 4486-4535 aa
Specificity: LRP1 Polyclonal Antibody detects endogenous levels of LRP1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human CD91 at the amino acid range 4486-4535
Post Translational Modifications Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane. The N-terminus is blocked. Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.
Function Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
Protein Name Prolow-Density Lipoprotein Receptor-Related Protein 1
Lrp-1
Alpha-2-Macroglobulin Receptor
A2mr
Apolipoprotein E Receptor
Apoer
Cd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit
Lrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit
Lrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain
Lrpicd
Database Links Reactome: R-HSA-2168880
Reactome: R-HSA-975634
Cellular Localisation Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit: Cell Membrane
Single-Pass Type I Membrane Protein
Membrane
Coated Pit
Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit: Cell Membrane
Peripheral Membrane Protein
Extracellular Side
Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain: Cytoplasm
Nucleus
After Cleavage
The Intracellular Domain (Lrpicd) Is Detected Both In The Cytoplasm And In The Nucleus
Golgi Outpost
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Localizes To The Postsynaptic Golgi Apparatus Region
Also Named Golgi Outpost
Which Shapes Dendrite Morphology By Functioning As Sites Of Acentrosomal Microtubule Nucleation
Alternative Antibody Names Anti-Prolow-Density Lipoprotein Receptor-Related Protein 1 antibody
Anti-Lrp-1 antibody
Anti-Alpha-2-Macroglobulin Receptor antibody
Anti-A2mr antibody
Anti-Apolipoprotein E Receptor antibody
Anti-Apoer antibody
Anti-Cd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit antibody
Anti-Lrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit antibody
Anti-Lrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain antibody
Anti-Lrpicd antibody
Anti-LRP1 antibody
Anti-A2MR antibody
Anti-APR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance