Anti-LPCAT1 antibody (325-534) (STJ27005)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LPCAT1 (325-534) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LPCAT1 |
| Gene ID | 79888 |
| Uniprot ID | PCAT1_HUMAN |
| Immunogen Region | 325-534 |
| Immunogen Sequence | LPADTCLLEFARLVRGLGLK PEKLEKDLDRYSERARMKGG EKIGIAEFAASLEVPVSDLL EDMFSLFDESGSGEVDLREC VVALSVVCRPARTLDTIQLA FKMYGAQEDGSVGEGDLSCI LKTALGVAELTVTDLFRAID QEEKGKITFADFHRFAEMYP AFAEEYLYPDQTHFESCAET SPAPIPNGFCADFSPENSDA GRKPVRKKLD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 325-534 of human LPCAT1 (NP_079106.3). |
Additional Info
| Tissue Specificity | Erythrocytes. |
| Function | Exhibits acyltransferase activity. Exhibits acetyltransferase activity. Activity is calcium-independent. Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. Involved in the regulation of lipid droplet number and size. |
| Protein Name | Lysophosphatidylcholine Acyltransferase 1Lpc Acyltransferase 1Lpcat-1Lysopc Acyltransferase 11-Acylglycerol-3-Phosphate O-Acyltransferase1-Acylglycerophosphocholine O-Acyltransferase1-Alkenylglycerophosphocholine O-Acyltransferase1-Alkylglycerophosphocholine O-AcetyltransferaseAcetyl-Coa -Lyso-Platelet-Activating Factor AcetyltransferaseAcetyl-Coa -Lyso-Paf AcetyltransferaseLyso-Paf AcetyltransferaseLysopafatAcyltransferase-Like 2Phosphonoformate Immuno-Associated Protein 3 |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-1482925Reactome: R-HSA-1483166Reactome: R-HSA-1483191Reactome: R-HSA-6798695 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinGolgi Apparatus MembraneCell MembraneLipid DropletMay Adopt A Monotopic Topology When Embedded In The Lipid Monolayer Of The Lipid DropletWith Both Termini Exposed To The Cytoplasm |
| Alternative Antibody Names | Anti-Lysophosphatidylcholine Acyltransferase 1 antibodyAnti-Lpc Acyltransferase 1 antibodyAnti-Lpcat-1 antibodyAnti-Lysopc Acyltransferase 1 antibodyAnti-1-Acylglycerol-3-Phosphate O-Acyltransferase antibodyAnti-1-Acylglycerophosphocholine O-Acyltransferase antibodyAnti-1-Alkenylglycerophosphocholine O-Acyltransferase antibodyAnti-1-Alkylglycerophosphocholine O-Acetyltransferase antibodyAnti-Acetyl-Coa -Lyso-Platelet-Activating Factor Acetyltransferase antibodyAnti-Acetyl-Coa -Lyso-Paf Acetyltransferase antibodyAnti-Lyso-Paf Acetyltransferase antibodyAnti-Lysopafat antibodyAnti-Acyltransferase-Like 2 antibodyAnti-Phosphonoformate Immuno-Associated Protein 3 antibodyAnti-LPCAT1 antibodyAnti-AYTL2 antibodyAnti-PFAAP3 antibody |
Information sourced from Uniprot.org