Anti-LPAR2 antibody (250-350) (STJ117019)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LPAR2 (250-350) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LPAR2 |
| Gene ID | 9170 |
| Uniprot ID | LPAR2_HUMAN |
| Immunogen Region | 250-350 |
| Immunogen Sequence | FVVCWTPGQVVLLLDGLGCE SCNVLAVEKYFLLLAEANSL VNAAVYSCRDAEMRRTFRRL LCCACLRQSTRESVHYTSSA QGGASTRIMLPENGHPLMDS T |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human LPAR2 (NP_004711.2). |
Additional Info
| Tissue Specificity | Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon. |
| Function | Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. |
| Protein Name | Lysophosphatidic Acid Receptor 2Lpa Receptor 2Lpa-2Lysophosphatidic Acid Receptor Edg-4 |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-418594Reactome: R-HSA-419408 |
| Cellular Localisation | Cell SurfaceCell MembraneMulti-Pass Membrane ProteinPrior To Lpa Treatment Found Predominantly At The Cell Surface But In The Presence Of Lpa Colocalizes With Rala In The Endocytic Vesicles |
| Alternative Antibody Names | Anti-Lysophosphatidic Acid Receptor 2 antibodyAnti-Lpa Receptor 2 antibodyAnti-Lpa-2 antibodyAnti-Lysophosphatidic Acid Receptor Edg-4 antibodyAnti-LPAR2 antibodyAnti-EDG4 antibodyAnti-LPA2 antibody |
Information sourced from Uniprot.org